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  7. Clozapine, Tocris Bioscience™

Clozapine, Tocris Bioscience™

Catalog No. 0444500
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Quantity:
50 mg
500 mg
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This item is not returnable. View return policy

Description

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

Chemical Identifiers

CAS 5786-21-0
Molecular Formula C18H19ClN4
Molecular Weight (g/mol) 326.828
InChI Key ZUXABONWMNSFBN-UHFFFAOYSA-N
Synonym clozapine, leponex, clozapin, clozaril, fazaclo, clorazil, iprox, clozapinum, asaleptin, clozapina
PubChem CID 2818
IUPAC Name 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
SMILES CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Specifications

Quantity 500 mg
Formula Weight 326.83
Percent Purity >99%
Chemical Name or Material Clozapine

Safety and Handling

Recommended Storage Store at Room Temperature
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