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Gibco™ CTS™ TrueCut™ Cas9 Protein

Gibco™ CTS TrueCut Cas9 Protein is our highest performing CRISPR-Cas9 protein, engineered to deliver maximum ribonucleoprotein (RNP)-editing efficiency.

Supplier:  Gibco™ A45220

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Catalog No. A45220


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Description

Description

Gibco CTS TrueCut Cas9 Protein is our highest performing CRISPR-Cas9 protein, engineered to deliver maximum ribonucleoprotein (RNP)-editing efficiency. This protein is manufactured in compliance with standards for Ancillary Materials for Cell, Gene and Tissue-Based Products and is subjected to stringent quality specifications. It is provided in a high-concentration and large-scale format for process development and clinical research applications.

Features of CTS TrueCut Cas9 Protein include:
Consistent high editing efficiency—superior CRISPR-Cas9 editing efficiency in all tested cell lines including primary immune cells (>90% editing in primary T cells)
Higher stringency manufacturing—manufactured to meet the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products including USP <1043>, Ph.Eur. 5.2.12, and ISO 20399, following the principles of 21 CFR Part 820 in a FDA-registered manufacturing site
Aseptic manufacturing—entire process completed using single-use technology
Extensive safety testing—includes sterility, endotoxin, mycoplasma, residual nucleic acids, and proteins
Sterile filling—finished product is vialed in a Class A/B (Class 100 and ISO 5 equivalents) cleanroom
Traceability documentation—COA, COO, Drug Master Files, and Regulatory Support Files are available

CTS TrueCut Cas9 Protein is a Streptococcus pyogenes Cas9 (wt) protein, produced by recombinant DNA technology in E. coli for genome editing with CRISPR technology. Cas9 protein forms a very stable RNP complex with the guide RNA (gRNA) component of the CRISPR/Cas9 system. Incorporation of NLS aids delivery to the nucleus, increasing the editing efficiency and on-target cleavage.

If you would like to evaluate our TrueCut Cas9 protein or conduct small-scale research experiments, we recommend using our TrueCut Cas9 Protein v2 (Cat. No. A36497).

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Specifications

Specifications

10 mg/mL
2.5 mg
Sterile-filtered
Dry Ice
Liquid
ISO13485
Cell and Gene Therapy Research, Development, and Manufacturing
Cas9 Protein
Store at –20°C.
E. coli
Genome Editing
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Safety and Handling

Safety and Handling

ShelfLife : 36 months from date of manufacture

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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For Research Use or Non-Commercial Manufacturing of Cell-Based Products for Clinical Research. Caution: Not intended for direct administration into humans or animals.