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Endocannabinoids

Endocannabinoids

Endogenous, lipid-based retrograde transmitters that bind to cannabinoid receptors (CB1 and CB2); regulate several physiological conditions and numerous diseases including fertility, immunological activity, appetite, mood, memory, and pain sensation.

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1

2-Arachidonylglycerol, Tocris Bioscience™

CAS: 53847-30-6 Molecular Formula: C23H38O4 Molecular Weight (g/mol): 378.55 MDL Number: MFCD01862600 InChI Key: RCRCTBLIHCHWDZ-DOFZRALJSA-N Synonym: 2-arachidonoylglycerol,2-arachidonylglycerol,2-ag,2-arachidonyl-glycerol,2-arachidonoyl-glycerol,2-arachidonoyl glycerol,2-ara-gl,glyceryl 2-arachidonate,2-monoarachidonoylglycerol,unii-8d239qdw64 PubChem CID: 5282280 ChEBI: CHEBI:52392 IUPAC Name: 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate SMILES: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO

PubChem CID 5282280
CAS 53847-30-6
Molecular Weight (g/mol) 378.55
ChEBI CHEBI:52392
MDL Number MFCD01862600
SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO
Synonym 2-arachidonoylglycerol,2-arachidonylglycerol,2-ag,2-arachidonyl-glycerol,2-arachidonoyl-glycerol,2-arachidonoyl glycerol,2-ara-gl,glyceryl 2-arachidonate,2-monoarachidonoylglycerol,unii-8d239qdw64
IUPAC Name 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
InChI Key RCRCTBLIHCHWDZ-DOFZRALJSA-N
Molecular Formula C23H38O4
2

Enzo Life Sciences Noladin ether (5mg). CAS: 222723-55-9
SDP

Endogenous cannabinoid agonist isolated from porcine brain. Binds specifically to CB1 (Ki=21.2nM) and CB2 (Ki=>3µM) receptors. Causes sedation hypothermia, intestinal immobility and mild antinociception in mice. Chemically stable, but less potent than 2-arachidonoylglycerol (BML-FA028) with an endogenous half-life time of hours rather than minutes. Alternative name: 2-Arachidonyl glyceryl ether, 2-AG ether, 5Z,8Z,11Z,14Z-Eicosatetraen-2-glyceryl ether. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (40mg/ml) or ethanol (25mg/ml). Long Term Storage: -20°C.

ENCOMPASS_PREFERRED
3

Eurofins Discoverx 2-Arachidonylglycerol, 10 mg. (92-1226)

2-Arachidonylglycerol is an endocannabinoid ester formed by arachidonic acid and glycerol that is expressed in the CNS at much higher levels than anandamide. Has neuromodulatory effects, and is a potent agonist of the GPR55, CB1, and CB2 receptors (EC50=3, 519, and 618 nM, respectively). Provided as 10 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter,  PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.

ENCOMPASS_PREFERRED